2025 NFL Week 12 Betting Preview

After a wild Week 11, teams head into NFL Week 12 hoping to make the final push to the 2025-2026 NFL Playoffs. One team in search of a win will be the Kansas City Chiefs after Patrick Mahomes and his mates fell to the Denver Broncos in Week 11. Teams hoping to continue their good fortune include the New England Patriots and the hot LA Rams. Keep reading for NFL odds, analysis, and free picks for NFL Week 12.

Top 2025 NFL Week 12 Games to Bet On

New England Patriots vs. Cincinnati Bengals

• When: Sunday, November 23rd. 1:00 p.m. ET

• NFL Week 12 Odds: Patriots -385 / Bengals +300

The Patriots won their eighth straight in Week 11, trouncing the rival New York Jets 27-14. Drake Maye has emerged as the favorite to win the NFL MVP, which makes sense because the Pats are playing like the best team in the AFC.

The Bengals looked good on their first drive against the Pittsburgh Steelers, but then fell apart the rest of the way, losing 34-12. But it feels like the Pats are due for a letdown. Go Bengals.

2025 NFL 12 Pick: Bengals

Minnesota Vikings vs. Green Bay Packers

• When: Sunday, November 23rd. 1:00 p.m. ET

• NFL Week 12 Odds: Vikings +245 / Packers -303

Vikings versus Packers is a classic rivalry. In this game, the Packers have a serious edge with Jordan Love at quarterback over J.J. McCarthy.

The young McCarthy has yet to put it together as a starting QB in the NFL. He hasn’t had enough reps. Playing at Lambeau won’t be easy, and even if Josh Jacobs can’t tote the pigskin on Sunday, the Pack has enough to get the cover win.

2025 NFL 12 Pick: Packers

Indianapolis Colts vs. Kansas City Chiefs

• When: Sunday, November 23rd. 1:00 p.m. ET

• NFL Week 12 Odds: Colts +155 / Chiefs -185

• When: Sunday, November 23rd. 1:00 p.m. ET

• NFL Week 12 Odds: Seahawks +129 / Rams -156

The Cardinals aren’t a great team. Still, I can’t believe the Jaguars put together two fantastic games in a row.

Coming off a stunning 35-6 win over the Chargers, a victory we should have seen coming considering the Bolts had to start Trevor Penning at left tackle, most believe the Jags have turned the corner. Not so. Jacksonville will bounce back in a game the Cards take straight up.

2025 NFL 12 Pick: Cardinals

Atlanta Falcons vs. New Orleans Saints

• When: Sunday, November 23rd. 4:25 p.m. ET

• NFL Week 12 Odds: Falcons -189 / Saints +150

The Falcons are the favorites over the Saints, even though Michael Penix Jr. is out. Atlanta has no shot of making the playoffs after losing their fifth game in a row, where they made Bryce Young to Tetairoa McMillan look like Joe Montana to Jerry Rice.

Yes, the ATL defense played that poorly. Tyler Shough made a massive leap from his first proper action, when he threw a pick, to his first start, when he completed over 70% of his passes, threw for 282 yards, and tossed 2 TDs to beat the Panthers. Shough makes it two straight wins for the Saints.

2025 NFL 12 Pick: Saints

Tampa Bay Buccaneers vs. Los Angeles Rams

• When: Sunday, November 23rd. 8:20 p.m. ET

• NFL Week 12 Odds: Buccaneers +265 / Rams -333

The Rams are due for a letdown game after beating the rival Seattle Seahawks in their last. But the Rams are a veteran squad in the right place, meaning quarterback Matthew Stafford is having one of the best seasons of his career.

The defense in LA has become the best in the NFL, and Baker and the Bucs play their second straight formidable opponent on the road after blowing a chance to beat Buffalo in Week 11. Rams get the cover.

2025 NFL 12 Pick: Rams

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