2025 College Football Week 12 Betting Preview
Indiana escaped Penn State, while Bama, Ohio State, and Texas A&M continued to roll, and Notre Dame showed that it belongs in the College Football Playoff Top 12. Heading into NCAAF Week 12, massive games await, including Oklahoma trying to get back into the CFP race. A win over Bama would do just that for the Sooners. Check out college football odds, analysis, and free picks for this week’s top games.
Top 2025 College Football Week 12 Games to Bet On
Nineteen spots in the Top 25 poll have new teams in a major shuffling a month before the College Football Playoff matchups are set.https://t.co/7dTTUiSC1j pic.twitter.com/m7Gl5e2jEE
— AP Top 25 (@AP_Top25) November 9, 2025
South Carolina vs. Texas A&M
- When: Saturday, November 15th. 12:00 p.m. ET
- strong>College Football Week 12 Odds: South Carolina +680 / Texas A&M -1111
A&M gets better by the week. The Aggies faced a top SEC rival, Missouri, on the road in College Football Week 11 and blasted their rivals 38-17. For sure, there are doubters. The Aggies took on Mizzou with the Tigers’ starting QB out with an injury.
Still, A&M dropped 38 onto Missouri’s stout defense. So the Aggies are for real. LaNoris Sellers and the Gamecocks are in some trouble.
2025 College Football Week 12 Pick: Texas A&M
Notre Dame vs. Pittsburgh
- When: Saturday, November 15th. 12:00 p.m. ET
- strong>College Football Week 12 Odds: Notre Dame -455 / Pittsburgh +330
Pittsburgh is a solid squad, and this is evident on the Panthers’ field, but Marcus Freeman’s defense has begun to assert itself. For sure, this year’s Navy team isn’t close to being as good as in the past couple of seasons.
The Irish D impressed nevertheless when holding the Middies to 10 points in a 49-10 pasting. Notre Dame covers in what should be an impressive road win over a ranked opponent.
2025 College Football Week 12 Pick: Notre Dame
Oklahoma vs. Alabama
- When: Saturday, November 15th. 3:30 p.m. ET0
- strong>College Football Week 12 Odds: Oklahoma +200 / Alabama -250
Some teams are rising. Alabama is one of them. Facing a reeling LSU squad, the Tide rolled the Baton Rouge Tigers 20-9.
Scoring only 20 may not impress, but LSU has a strong defense this season, and the Tigers were motivated to show they could hang with their top rivals. Bama’s D has started to play its best ball of the season. Give the Tide the win and cover.
2025 College Football Week 12 Pick: Alabama
Iowa vs. USC
- When: Saturday, November 15th. 3:30 p.m. ET
- strong>College Football Week 12 Odds: Iowa +180 / USC -227
Iowa heads to USC off an impressive 18-16 loss to Oregon. The Hawkeyes had a shot to knock off the Ducks but failed to close the deal. USC should be worried, right? Considering how well Iowa played versus Oregon?
Maybe not. Iowa is a different team on the road, and the Hawkeyes should feel some effects of the close loss. A negative bounce may be in Iowa’s future. Lay the points.
2025 College Football Week 12 Pick: USC
Florida vs. Ole Miss
- When: Saturday, November 15th. 7:00 p.m. ET
- strong>College Football Week 12 Odds: Florida +480 / Ole Miss -714
Ole Miss beat up the Citadel 49-0 in their last. We could say the Rebels were on a bye in Week 11. That may not be such a good thing for Mississippi.
3-6 Florida faces Ole Miss after a bye. So we should expect a strict performance from the Gators. Ah, then again, Florida lost to Kentucky 38-7 in their last. The Gators were hoping the season ended yesterday. Florida has no direction, no hope, and no desire to play football. Ole Miss rolls.
2025 College Football Week 12 Pick: Ole Miss
Texas vs. Georgia
- When: Saturday, November 15th. 7:30 p.m. ET
- strong>College Football Week 12 Odds: Texas +310 / Georgia -417
If there’s one possible upset on the schedule, this should be it. Texas’ defense might be better than Georgia’s this season. However, before considering the 6.5 points or backing Arch Manning and the Horns straight up, realize that Georgia is at home, and the Longhorns’ offensive line continues to be a disaster.
UGA should make a statement in this game. The Dawgs trounced Mississippi State 41-21 on the road in their last. Arch will have to be creative to keep the Georgia pass rush from putting him on the ground.
2025 College Football Week 12 Pick: Georgia
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*All stated odds are subject to change without prior notice.
